Things get a little trickier when one or both of your values are negative. The formula itself doesn't change, but the results can look strange if you're not expecting them.
Say a company reported a loss of $5,000 in March (−$5,000) and a loss of $2,000 in April (−$2,000). Plugging into the formula: (−2,000 − (−5,000)) / |−5,000| × 100 = 3,000 / 5,000 × 100 = 60% improvement. The loss shrank, so the percent change is positive, which makes sense directionally.
The trickiest case is when the original value is negative and the result is positive, or vice versa. In those situations, mathematicians often use the absolute value of the original number in the denominator to keep the sign of the result meaningful. Just flag it clearly when you share the number, because percent change with negative bases can mislead people who don't know the raw values.
When both numbers are negative and the value is getting more negative (i.e., things are getting worse), the percent change will also be negative. Use your common sense as a gut check alongside the formula.